Buy SLU-PP-332 Online

SLU-PP-332 is a synthetic small-molecule compound classified as an estrogen-related receptor (ERR) agonist. It primarily targets ERRα, with lesser activity on ERRβ and ERRγ. This compound has garnered attention in metabolic and aging research due to its potential to mimic the physiological effects of exercise and caloric restriction.

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🔬 Chemical Profile

• Chemical Name: 4-hydroxy-N-[(Z)-naphthalen-2-ylmethylideneamino]benzamide

• CAS Number: 303760-60-3

• Molecular Formula: C₁₈H₁₄N₂O₂

• SMILES Notation: C1=CC=C2C=C(C=CC2=C1)/C=NNC(=O)C3=CC=C(C=C3)O

• PubChem CID: 5404083

• InChI Key: RNZIMBFHRXYRLL-UNOMPAQXSA-N

The Z-configuration at the C=N double bond is crucial for optimal binding to the ERR ligand-binding domain, enhancing its biological activity.

⚙️ Mechanism of Action

SLU-PP-332 functions by activating ERRs, particularly ERRα, which plays a significant role in mitochondrial biogenesis and energy metabolism. Upon binding to ERRα, SLU-PP-332 stabilizes its active conformation, promoting the expression of genes involved in oxidative phosphorylation, fatty acid oxidation, and thermogenesis. This activation leads to increased mitochondrial function and enhanced cellular respiration in various tissues, including skeletal muscle, heart, and brain

🧪 Preclinical Findings

Research in animal models has demonstrated several promising effects of SLU-PP-332:

• Metabolic Syndrome and Obesity: Administration of SLU-PP-332 in mice resulted in an 18–24% reduction in body weight, a 30–35% decrease in white adipose tissue mass, and a 40% improvement in glucose tolerance.

• Exercise-Mimetic Effects: The compound enhanced mitochondrial density in skeletal muscle, increased vascularization, and improved endurance performance without additional physical activity.

• Aging and Mitochondrial Function: SLU-PP-332 alleviated age-related mitochondrial dysfunction and inflammation in kidney and liver tissues, suggesting potential applications in aging research

• Cardiac Protection: In models of heart failure, SLU-PP-332 preserved cardiac contractility, reduced cardiomyocyte apoptosis, and improved myocardial energetics

🧠 Potential Therapeutic Applications

Given its effects on mitochondrial function and energy metabolism, SLU-PP-332 is being investigated for potential therapeutic applications in:

• Type 2 Diabetes and Metabolic Syndrome: By improving insulin sensitivity and reducing adiposity, SLU-PP-332 may serve as a treatment option for metabolic disorders.

• Sarcopenia and Muscle Atrophy: The compound’s ability to enhance mitochondrial function and endurance may aid in combating age-related muscle loss.

• Neurodegenerative Diseases: Preliminary studies suggest that SLU-PP-332 could have applications in Alzheimer’s and Parkinson’s diseases through improved mitochondrial function

• Cardiovascular Health: Its cardioprotective effects indicate potential use in heart failure and ischemic heart conditions.